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KMID : 0385219950050020111
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Korean Journal of Gerontology
1995 Volume.5 No. 2 p.111 ~ p.116
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Effect of Docosahexaenoic Acid (DHA)-Rich Fish Oil on Experimental Induced Dementia, Alzheimer-Type 1. Effect of DHA on Lipid Metabolism in Rabbit
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Choi Jin-Ho
Kim Dong-Woo
Moon Young-Sil
Kim Yong-Sun
Kim Jae-Il
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Abstract
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New Zealand white rabbits were red commercial basic diets orally 5.0% 10% of docosahexaenoic acid(DHA)-rich fish oil including 31.95% of DHA for DHA-5 and DHA-10 groups for 80 day, and experimental Alzheimer’s disease were induced with injection of 1.0% aluminum chloride. Body weights gain were significantly inhibited after 50 days and 20 days in DHA-5 DHA-10 groups, respectively, compare with control group, these results may be due to decreases of their feed and gross efficiencies. Triglyceride(TG) and cholesterol levels in serum of rabbits were significantly higher in post-aluminum injection than in pre-aluminum injection , but significant difference between these DHA-administered groups could not be obtained. Cholestrol levels in brain microsomes of Alzheimer’s -induced rabbits were significantly decreased with administered doses of DHA-rich fish oil(p<0.05-p<0.01), but significant difference between these DHA-administered groups in brain miktochondria could not be obtained. LDL cholesteol levels and atherogenic index in serum of rabbits were significantly higher in post-aluminum injection than in pre-aluminum injection, whereas HDL cholesteol levels in serum of rabbits were significantly increased with post aluminum injection. It suggests that these results may be due to a strong toxicity ficantly increased with post-aluminum injection. It suggests that these results may be due to a strong toxicity or 1.0% aluminum chloride for induction of Alzheimer’s disease. Therefore, it is believed that injection of 1.0% aluminum chloride as a induction agent of Alzheimer’s disease is not suitable due to its strong toxicity.
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KEYWORD
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Alzheimer-type dementia, docosahexaenoic acid(DHA), triglyceride(TG), LDL and HDL cholesterol, atherogenic index, feed and gross efficiencies
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